4D Flow Cardiovascular Magnetic Resonance-Derived Flow Biomarkers for Early Detection of Flow Abnormalities: A Multicohort New Zealand Based Study

Four-dimensional (4D) flow cardiovascular magnetic resonance (4D CMR) imaging has evolved as a versatile technique for the assessment of three-dimensional time resolved haemodynamics. This study aimed to examine utility and metrics derived from 4D CMR in different patient cohorts. Controls (n=26), adult tetralogy Fallot (rToF; n=14), left ventricular hypertrophy (LVH; n=10) patients were scanned at Centre Advanced MRI, University Auckland. Quantification examination between-group differences performed. Intraclass correlation coefficients (ICC) used correlate 2D CMR. Forward rates averaged pulmonary veins significantly greater LVH than controls (79.11±54.24 mL/sec vs 32.58±35.98 mL/sec, respectively, p<0.05), was venous atrial reversal peak velocity (–0.44±0.23 m/sec –0.13±0.27 m/sec, p<0.05). Mitral indices net expressed no significant differences. In rToF group, quantification artery branches demonstrated good with Greatest between backward (difference s–2.50±6.91 mL/cycle, ICC 0.96). relation valve regurgitation categorisation, 1 14 cases differently categorised using (ICC 0.91). feasible, single acquisition introducing an array that may be valuable evaluation various conditions. Larger scale investigations are required, wider-scale application routine clinical workflows.